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| URL | https://doi.org/10.18429/JACoW-LINAC2024-THPB018 |
|---|---|
| Title | Medical activities in CLEAR: studies towards radiotherapy using Very High Energy Electrons (VHEE) in the FLASH regime |
| Authors |
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| Abstract | Given the present availability of high-gradient accelerator technology for compact and cost-effective electron linacs in the 100-200 MeV energy range, the interest for Very High Energy Electron (VHEE) radiotherapy (RT) for cancer treatment recently reached an all-time high. Particular significance is assumed by the Ultra-High Dose Rate (UHDR) regime where the so-called FLASH biological effect takes place, in which cancer cells are damaged while healthy tissue is largely spared. VHEE beams from linacs are especially well adapted for FLASH RT, given their penetration depth and the high beam current needed to treat large deep-seated tumours. In recent years, several multidisciplinary user groups carried out a number of studies on VHEE and FLASH RT issues using the CERN Linear Accelerator for Research (CLEAR) user facility, in close collaboration with the local operation team. In this paper we give an overview of such activities and describe the main results of chemical and biological tests aimed at clarifying the damage mechanisms at the root of the FLASH effect and the relevant beam parameters needed to achieve it. We also describe the dedicated systems and methods developed and used in CLEAR for these activities, focusing on recent advances in the crucial aspects of uniform beam delivery and high dose rate real-time dosimetry. |
| Paper | download: THPB018.pdf |
| Cite | BibTeX, LaTeX, Text/Word, RIS, EndNote |
| Conference | 32nd Linear Accelerator Conference (LINAC2024) |
| Series | |
| Location | Chicago, IL, USA |
| Date | 25-30 Aug 2024 |
| Publisher | JACoW Publishing, Geneva, Switzerland |
| Editorial Board | Kelly Jaje (ANL), Kip Bishofberger (LANL), Ryan Brody (ANL), Gustavo Bruno (ANL), Jan Chrin (PSI), Cathy Eyberger (ANL), Maggie Montes (SLAC), Denise Skiadopoulos (ANL), Ling Wang (MSU/FRIB), Kent Wootton (ANL) |
| Online ISBN | 978-3-95450-219-6 |
| Online ISSN | 2226-0366 |
| Received | 20 August 2024 |
| Revised | 28 August 2024 |
| Accepted | 29 August 2024 |
| Issued | 23 October 2024 |
| DOI | 10.18429/JACoW-LINAC2024-THPB018 |
| Pages | 674-677 |
| Copyright | Published by JACoW Publishing under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s), the published article's title, publisher, and DOI. |