| Title |
FLUKA Simulations of ²²⁵Ac Production Using Electron Accelerators: Validation Through Comparison with Published Experiments |
| Authors |
- T.V. Szabo, I.C. Moraes
CNPEM, Campinas, SP, Brazil
- F.A. Bacchim Neto
LNLS, Campinas, Brazil
- P.V. Guillaumon
USP/LAL, Sao Paulo, Brazil
- H.B. de Oliveira
IPEN, São Paulo, Brazil
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| Abstract |
Targeted Alpha Therapy (TAT) is an active area of study worldwide. This technique has shown a potential in nuclear medicine to treat metastatic disease by alpha particles that deposit energy in small regions nearby cancer cells. Ac-225 is an important alpha-emitting that can be used for cancer TAT. This radioisotope shows good potential for medical applications, therefore is important to study ways of increase its production and availability. One possible path for the Ac-225 product is to radiate a radium target (Ra-226) on a linear electron accelerator (LINAC). Isotope production studies could be implemented using computational tools. In this work, Monte Carlo simulations with FLUKA code were performed and compared to experimental results *. We studied Ac-225 production by photonuclear reactions using a 24 MeV electron beam LINAC hitting a tungsten electron-photon converter. Different energies and geometries were also simulated to obtain optimal production conditions. The specific activity values obtained with simulations had a good agreement with published experimental results.
|
| Footnotes & References |
* MASLOV, O., et. al. Preparation of 225Ac by 226Ra(g, n) photonuclear reaction on an mt25 microtron. Radiochemistry |
| Paper |
download MOPAB409.PDF [0.330 MB / 3 pages] |
| Export |
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| Conference |
IPAC2021 |
| Series |
International Particle Accelerator Conference (12th) |
| Location |
Campinas, SP, Brazil |
| Date |
24-28 May 2021 |
| Publisher |
JACoW Publishing, Geneva, Switzerland |
| Editorial Board |
Liu Lin (LNLS, Campinas, Brazil); John M. Byrd (ANL, Lemont, IL, USA); Regis Neuenschwander (LNLS, Campinas, Brazil); Renan Picoreti (LNLS, Campinas, Brazil); Volker R. W. Schaa (GSI, Darmstadt, Germany) |
| Online ISBN |
978-3-95450-214-1 |
| Online ISSN |
2673-5490 |
| Received |
19 May 2021 |
| Accepted |
09 June 2021 |
| Issue Date |
30 August 2021 |
| DOI |
doi:10.18429/JACoW-IPAC2021-MOPAB409 |
| Pages |
1226-1228 |
| Copyright |
 Published by JACoW Publishing under the terms of the Creative Commons Attribution 3.0 International license. Any further distribution of this work must maintain attribution to the author(s), the published article's title, publisher, and DOI. |
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