| Title |
A Comparative Study of Biological Effects of Electrons and Co-60 Gamma Rays on pBR322 Plasmid DNA |
| Authors |
- K.L. Small, R.M. Jones
UMAN, Manchester, United Kingdom
- D. Angal-Kalinin, M. Surman
Cockcroft Institute, Warrington, Cheshire, United Kingdom
- A. Chadwick, N.T. Henthorn, K. Kirkby, M.J. Merchant, R. Morris, E. Santina
The Christie NHS Foundation Trust, Manchester, United Kingdom
- R. Edge
Dalton Cumbrian Facility, University of Manchester, Cumbria, United Kingdom
- R.J. Smith
STFC/DL/ASTeC, Daresbury, Warrington, Cheshire, United Kingdom
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| Abstract |
Very High-Energy Electron (VHEE) therapy is a rapidly developing field motivated by developments in high-gradient linacs. Advantages include sufficient penetration (>30 cm) for treatment of deep-seated tumours, measured insensitivity to inhomogeneities and rapid delivery time, making VHEE viable for treatment of heterogeneous regions, e.g. lung or bowel. Researchers at the University of Manchester and CERN have routinely produced accelerating gradients of ~100 MeV/m for the CLIC project. Suitable modification can result in a high gradient medical linac producing 250 MeV electrons within a treatment room. Radiobiological research for VHEE is vital to understand its use in radiotherapy and how it compares with conventional modalities. The goal of radiotherapy is to destroy tumour cells while sparing healthy cells, primarily by damaging DNA within the cancer cell. The study aim is to understand the fundamental interactions between VHEE and biological structures through plasmid irradiation studies - both computational, using the Monte Carlo GEANT4-DNA code, and experimental. Plasmid irradiation experiments have been carried out at using Co-60 gammas at the Dalton Cumbrian Facility and using 6-15 MeV electrons at the Christie NHS Foundation Trust to determine the type and quantity of damage caused to DNA by electron irradiation. These experiments are a world first in VHEE radiobiology, with further studies planned at higher energies using the CLARA and CLEAR facilities at Daresbury and CERN. These studies will also consider the effective dose range of VHEE with energy, as well as implications of damage on DNA. Research into this area of radiotherapy can provide a valuable addition to tools currently available to physicians in the fight against cancer.
|
| Paper |
download THPMP041.PDF [1.757 MB / 4 pages] |
| Export |
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| Conference |
IPAC2019 |
| Series |
International Particle Accelerator Conference (10th) |
| Location |
Melbourne, Australia |
| Date |
19-24 May 2019 |
| Publisher |
JACoW Publishing, Geneva, Switzerland |
| Editorial Board |
Mark Boland (UoM, Saskatoon, SK, Canada); Hitoshi Tanaka (KEK, Tsukuba, Japan); David Button (ANSTO, Kirrawee, NSW, Australia); Rohan Dowd (ANSTO, Kirrawee, NSW, Australia); Volker RW Schaa (GSI, Darmstadt, Germany); Eugene Tan (ANSTO, Kirrawee, NSW, Australia) |
| Online ISBN |
978-3-95450-208-0 |
| Received |
15 May 2019 |
| Accepted |
22 May 2019 |
| Issue Date |
21 June 2019 |
| DOI |
doi:10.18429/JACoW-IPAC2019-THPMP041 |
| Pages |
3533-3536 |
| Copyright |
 Published by JACoW Publishing under the terms of the Creative Commons Attribution 3.0 International license. Any further distribution of this work must maintain attribution to the author(s), the published article's title, publisher, and DOI. |
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