Leonarski, F. Brückner, M. Lopez-Cuenca, C. Mozzanica, A. Stadler Kleeb, H.C. Wang, M. JACoW Publishing Geneva, Switzerland The Swiss Light Source (SLS) will shortly start an upgrade to become a 4th generation light source. The higher brilliance of the new source brings new science opportunities - one of them is improving time resolution for X-ray crystallography to a microsecond regime. However, fully utilizing the new machine will require increasing the frame rate of pixel array detectors and, thus, data volume. Nine-megapixel JUNGFRAU detector planned for SLS 2.0 beamlines will generate up to 36 GB/s raw data when operated at 2 kHz, which is very challenging for computing infrastructure. To operate this JUNGFRAU detector, PSI has developed a ’Jungfraujoch’ read-out system. The system can handle the complete data rate within a single server box for fast deployment at various beamlines. The system uses FPGA smart network interface cards for data acquisition, GPUs for on-the-fly image analysis (e.g., spot finding, radial integration), and high-end CPUs for image compression. In the presentation, I will show Jungfraujoch’s capabilities, experience from time-resolved macromolecular crystallography beamtimes, and technical details. I will highlight how FPGA design with high-level languages (C/C++) can help software developers design programmable logic quickly and how it can help in rapid verification. I will also present experiences working with a memory-coherent interconnect (OpenCAPI) to integrate FPGA boards into the server system and how it compares with a mainstream peripheral bus (PCI Express).