| Title |
MiniBEE - Minibeam Beamline for Preclinical Experiments |
| Authors |
- J. Reindl, G. Datzmann, G. Dollinger, J. Neubauer, A. Rousseti
Universität der Bundeswehr Muenchen, Neubiberg, Germany
- J. Bundesmann, A. Denker, A. Dittwald, G. Kourkafas
HZB, Berlin, Germany
- G. Datzmann
Datzmann Interact & Innovate GmbH, München, Germany
- A. Denker
BHT, Berlin, Germany
|
| Abstract |
Spatial fractionated radiotherapy using protons, so-called proton minibeam radiotherapy (pMBT) was developed for better sparing of normal tissue in the entrance channel of radiation. Progressing towards clinical use, pMBT should overcome current technical and biomedical limitations. This work discusses a preclinical pMBT facility, currently built at the 68.5MeV cyclotron at the Helmholtz Zentrum Berlin. The goal is to irradiate small animals using focused pMBT with a σ of 50µm, a high peak-to-valley dose ratio at center-to-center distance as small as 1mm and beam current of 1nA. A first degrader defines the maximum energy of the beam. Dipole magnets and quadrupole triplets transport the beam to the treatment room while multiple slits properly form the transverse beam profiles. A high magnetic field gradient triplet lens forms the minibeams in front of the target station and, scanning magnets are used for a raster scan at the target. An additional degrader, positioned close before the focusing spot and the target, further reduces the energy, forming a spread-out Bragg peak. A small animal radiation research platform will be used for imaging and positioning of the target.
|
| Paper |
download MOP002.PDF [0.577 MB / 3 pages] |
| Cite |
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| Conference |
IBIC2023 |
| Series |
International Beam Instrumentation Conference (12th) |
| Location |
Saskatoon, Canada |
| Date |
10-14 September 2023 |
| Publisher |
JACoW Publishing, Geneva, Switzerland |
| Editorial Board |
Volker R.W. Schaa (GSI, Darmstadt, Germany); Tonia Batten (CLS, Saskatoon, Canada); Michael Bree (CLS, Saskatoon, Canada); Christine Petit-Jean-Genaz (CERN, Geneva, Switzerland); Darren Hunter (CLS, Saskatoon, Canada) |
| Online ISBN |
978-3-95450-236-3 |
| Online ISSN |
2673-5350 |
| Received |
09 September 2023 |
| Revised |
14 September 2023 |
| Accepted |
25 September 2023 |
| Issue Date |
29 September 2023 |
| DOI |
doi:10.18429/JACoW-IBIC2023-MOP002 |
| Pages |
34-36 |
| Copyright |
 Published by JACoW Publishing under the terms of the Creative Commons Attribution 4.0 International license. Any further distribution of this work must maintain attribution to the author(s), the published article's title, publisher, and DOI. |
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