Warner, A. Austin, M.R. Carmichael, L.R. Carneiro, J.-P. Hanna, B.M. Harms, E.R. Ibrahim, M.A. Neswold, R. Prost, L.R. Rivera, R.A. Shemyakin, A.V. Wu, J.Y. JACoW Publishing Geneva, Switzerland 2673-5350 978-3-95450-241-7 10.18429/JACoW-IBIC2022-TUP05 English 229-232 MEBT controls hardware operation MMI Contribution to a conference proceedings 2022 2022-12 https://doi.org/10.18429/JACoW-IBIC2022-TUP05 https://jacow.org/ibic2022/papers/tup05.pdf The PIP2IT accelerator was assembled in multiple stages in 2014 - 2021 to test concepts and components of the future PIP-II linac that is being constructed at Fermilab. In its final configuration, PIP2IT accelerated a 0.55 ms x 20 Hz x 2 mA H⁻ beam to 16 MeV. To protect elements of the beam line, a Machine Protection System (MPS) was implemented and commissioned. The beam was interrupted faster than 10 µs when excessive beam loss was detected. The paper describes the MPS architecture, methods of the loss detection, procedure of the beam interruption, and operational experience at PIP2IT.