Petringa, G. Cirrone, G.A.P. JACoW Publishing Geneva, Switzerland Laser-generated radiation represent one of the frontiers of the acceleration techniques. When a TW level, fs duration laser is focused in small spot size, the radiation pressure triggers physics processes able to accelerate ions with intensities of the order of E9-E11 particles/steradians. Laser driven ion acceleration has several applications. The development of laser-accelerated proton irradiation systems was proposed by many research group. The Czech pillar of ELI site, includes the ’ELIMED’ beamline, devoted to exploring medical applications of laser-driven proton beams. Radioisotope production is another potential medical application, but many other are of interest such as high-resolution proton radiography, nuclear reactions and the development of laser-driven high-brightness injectors. All these applications require the detectors and diagnostic systems able to detect these high intense beams. In this talk an overview on the last approaches of laser-driven ion acceleration and diagnostic will be presented. Advanced solutions on detectors development will be presented with a critical discussion on the current limitations and potential future achievable progresses.